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Exercise has been recommended to patents with nonalcoholic fatty liver disease to help with weight loss. But Japanese researchers have found that the beneficial effects of exercise extend beyond weight management. They followed men on a three-month exercise regimen and, in addition to better preservation of muscle mass, found that participants exhibited reduced liver steatosis and fibrosis.
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— Kate Jackson, editor |
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Exercise for Liver Health
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting as much as one-quarter of humanity. It is characterized by fat accumulation in liver cells and may progress to inflammation, cirrhosis, and liver failure. Now, researchers at the University of Tsukuba reveal the positive effects, beyond the expected weight-loss benefit, of exercise on the liver.
NAFLD is associated with unhealthy behaviors such as overeating and a sedentary lifestyle. In Japan, 41% of middle-aged men have NAFLD, and 25% will progress to nonalcoholic steatohepatitis (NASH) and hepatic dysfunction.
Weight reduction is fundamental to NAFLD management. Unfortunately, achieving a targeted bodyweight without supervision is difficult, and maintaining this over time even more so. Hitherto, exercise was considered adjunctive to dietary restrictions for weight loss, but the other benefits such as reduced hepatic steatosis (fatty change) and stiffness are being increasingly recognized. However, the underlying mechanisms remain unclear.
“We compared data from obese Japanese men with NAFLD on a three-month exercise regimen with those on dietary restriction targeting weight loss,” explains Junichi Shoda, MD, PhD, a professor at the University of Tsukuba and senior author. “We tracked hepatic parameters, reduction in adipose tissue, increase in muscle strength, reductions in inflammation and oxidative stress, changes in organokine concentrations, and expression of target genes of Nrf2, an oxidative stress sensor.”
Full story » |
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Dynamic Vision
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Social Determinants & Stroke
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The House Call Comeback
A system of personalized medicine could have a positive impact on geriatric patients. Read more » |
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Racism in Medical Journals
In the wake of the departure of a top editor of JAMA following a controversy sparked by a colleague’s comments on a podcast, a conversation about racism in biomedical literature has opened, prompting a plan by JAMA editors to improve diversity among its staff. The New York Times reports on the dearth of articles in the medical literature addressing racism.
New Tool Activates Deep Brain Neurons
Science News reports on the first research indicating that by stimulating a target in the brain, sonothermogenetics is able to control behavior. A multidisciplinary team at Washington University in St. Louis developed the new brain stimulation technique that works without the implantation of a surgical device.
Is COVID Revolutionizing Health Care?
For all the devastation it’s caused, COVID-19 may have long-lasting positive effects on health care. As Time magazine reports, “The pandemic has wrought immense suffering while simultaneously accelerating the adoption of new ways to improve global health.” Time reports on new modes of health care delivery; innovation in the research, development, and manufacture of new health technologies; advances in combating medical misinformation; and more.
New Promise for Women With Hereditary Breast Cancer
There may be a new weapon against breast cancer related to BRCA1 and BRC2 genes. According to research published in the New England Journal of Medicine and reported in The Guardian, a trial of a new drug, olaparib, was stopped early due to results showing it reduced the relative risk of death, second cancers, and invasive recurrence by more than 40%. |
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Medical Garments With Complete Coverage
To help reduce patient anxiety and improve comfort for surgery patients, COVR offers complete coverage medical garments that ensure patient privacy, dignity, and comfort during surgical procedures and postsurgical care yet allow surgeons needed access. Learn more »
Around-the-Clock Virtual Care
Cloud DX and Maxwell Telecare have teamed to bring ’round-the-clock virtual care and real-time vital sign monitoring to residents in long term care facilities. The new solution, which combines Maxwell Telecare’s on-demand telemedicine for postacute care with Cloud DX’s remote patient monitoring and diagnostic platform, is available now to health care partners in the US Midwest and Northwest. Learn more about Maxwell Telecare and Cloud DX. |
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