E-news Exclusive

Osteoporosis: A Risk Factor for Men

Men with high levels of body fat have lower bone density and may be more likely to break a bone than those with normal levels of body fat, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Most studies have shown positive or neutral effects of body fat mass—the weight of fat in your body—on bone health. Lean mass is the entire weight of your body, including organs, skin, and bones, minus fat. Health care providers often assume people with higher body weight have high bone density and are at low risk of fracture, and these patients are less likely to be screened for osteoporosis.

“We found that higher fat mass was related to lower bone density, and these trends were stronger in men than women,” says Rajesh K. Jain, MD, of University of Chicago Medicine. “Our research suggests that the effect of body weight depends on a person's makeup of lean and fat mass, and that high body weight alone is not a guarantee against osteoporosis.” Tamara Vokes, MD, of University of Chicago Medicine is the coauthor of the study.

The researchers analyzed the bone mineral density and body composition data of 10,814 people younger than 60 years old from the National Health and Nutrition Examination Survey 2011–2018. They found a strong positive association between lean mass and bone mineral density in both men and women. Conversely, fat mass had a moderately negative association with bone mineral density, especially in men.

“Health care providers should consider osteoporosis screening for patients with high body weight, especially if they have other risk factors like older age, previous fracture, family history, or steroid use,” Jain says.

— Source: Endocrine Society